Sentence examples for mediator of host from inspiring English sources

Because the entire orientation of the science regarded immunity as a mediator of host defense, so-called autoimmune reactions were originally viewed as pathological.

In the present study we investigated the role of SP-A as a mediator of host defense against the pulmonary pathogen, C. neoformans.

First, acapsular strains of C. neoformans are uniformly avirulent, not clinically relevant and thus would not be suitable for investigating the role of SP-A as a mediator of host defense.

Nitric oxide (NO) is an important mediator of host defence and of vascular tone.

IL-6, a proinflammatory cytokine, is a major mediator of host response to inflammation and infection.

Furthermore, we monitored the local IFN-gamma response during the acute phase of the infection, because of its important role as a mediator of host resistance against Toxoplasma as demonstrated in mice, sheep and humans [ 17, 22, 23].

However, iron is also a critical mediator of host-pathogen interactions, and supplementation may have serious adverse consequences in areas of high infectious burden.

The pro-inflammatory cytokine IL-1β is a key mediator of host-defence responses, which also contributes to the pathogenesis of diverse diseases 1.

The fungal cell wall is a critical mediator of host-pathogen interactions, and extensive remodeling is required during germination and other differentiation events during pathogenesis.

The apparent role of the pneumococcal pilus as an important mediator of host-bacterial interactions has led to its consideration as a part of a multicomponent second-generation serotype-independent vaccine that is currently undergoing evaluation (8, 15).

Toll-like receptors (TLRs) are essential mediators of host immunity.