In total, these results implicate a small number of genes, particularly a cluster related to dopamine D1 signalling in the PFC, as being related to and potentially as being mediators of general cognitive abilities (c.f., general intelligence).
Representative images can be found in Additional files 3 and 4. We have employed 4T1 breast cancer subpopulations, derived from primary mammary tumors or bone, lung and liver metastases, to identify potential mediators of general or organ-specific breast cancer metastasis.
Furthermore, LASP-1 also directly binds the CTD of CXCR1, CXCR3 and CXCR4, suggesting that LASP-1 is a general mediator of CXC chemokine mediated chemotaxis.
Ahn, S. et al. A dominant negative inhibitor of CREB reveals that it is a general mediator of stimulus-dependent transcription of c-fos.
It was initially proposed that cellular oxidative stress could be a general mediator of apoptosis [26].
In the present study, mouse ICH model was used to provide proof-of-principle that hNSCs genetically modified to express Akt1, a general mediator of cell survival signals, can be transplanted in the brain of animal models of neurological diseases, and produces beneficial effects of increased survival of grafted NSCs and consequent functional recovery.
Considering evidence of functional recovery in stroke animals following brain transplantation of human NSCs and Akt1 protein as a general mediator of survival signals, the present study is designed to investigate whether human NSCs overexpressing Akt1 can lead to the prolonged cell survival of grafted human NSCs and functional recovery in the mouse ICH stroke model.
These results are consistent with previous studies that Akt1, protein which is known as a general mediator of cell survival signals, promotes the survival of CNS neurons in vitro [23], [27] [29], and provides favorable clinical outcome in animal models of ischemia [36].
One possible way to promote extended survival of transplanted NSCs in animal brain is to modulate properties of the NSCs, and this might be accomplished by over-expressing Akt1 protein which is known as a general mediator of cell survival signals in the NSCs.
We find this function is constant in multiple tissues defining c-Myc as a general mediator of apoptosis in vivo.
