Sentence examples for mediator of experimental from inspiring English sources

Similarly, a recent study of P. berghei ANKA implicated C5a as an early mediator of experimental cerebral malaria [53].

The ubiquitous nuclear protein HMGB1 is released by activated macrophages/monocytes, and functions as a late mediator of experimental sepsis.

Taken together, these data establish HMGB1 as a late mediator of experimental sepsis with a wider therapeutic window than early mediators such as TNF.

Taken together, these experimental data establish extracellular HMGB1 as a critical late mediator of experimental sepsis, with a wider therapeutic window than early pro-inflammatory cytokines (Fig. 3).

Here we review emerging evidence that support extracellular HMGB1 as a late mediator of experimental sepsis, and discuss the therapeutic potential of several HMGB1-targeting agents (including neutralising antibodies and steroid-like tanshinones) in experimental sepsis.

Both GM-CSF and IL-17 are produced by T cells and are critical mediators of experimental arthritis [ 8, 13, 19, 23, 34, 35].

Also, MAOs have emerged as mediators of experimental endothelial dysfunction via the excessive H2O2 production in two murine models of acute (induced with lipopolysaccharide, LPS) and chronic (induced with angiotensin II and A II) oxidative stress, respectively [ 12].

Here, we briefly review the prevailing theories of sepsis as an uncontrolled systemic inflammatory response, and discuss potential therapeutic agents that target clinically more feasible, late-acting mediators of experimental sepsis, such as HMGB1.

As a mediator of inflammation, there is experimental evidence linking inflammasomes and their products to GI cancers.

In addition, peripheral Gr-1-positive cells of IVIG-treated animals showed reduced expression of the activating Fcγ receptor IV, which we recently described as a major mediator of tissue injury in experimental EBA.

The endothelial specific angiopoietin (Ang -Tie2 ligAng -Tie2tor system has been identified as a non-redundant mediator of endothelial activation in experimental sepsis.