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PGE2, an inflammatory mediator, is also a neuromodulator that may alter neuronal excitability and synaptic transmission [113].

Lastly, if a mediator is also the member of the same group and part of communication as well then s/he is the coordinator (Gould and Fernandez 1989).

This inflammatory mediator is also associated to the VEGF signalling pathway, and we found activation of several genes in this pathway after SE (Table 1; Fig. S3).

This inflammatory mediator is also associated to the VEGF signalling pathway supporting the idea of recent studies that seizures promote angiogenesis [13], [70], which could contribute to the recovery process after SE.

The role of the AT1B receptor as a pro-inflammatory mediator is also confirmed in myelin oligodendrocyte glycoprotein-induced experimental autoimmune encephalomyelitis (MOG-EAE), another mouse model of MS (Stegbauer et al, 2009).

M0 = 0 to rule out any reference interaction so that in absence of exposure the mediator is also absent; and (Y10 −  Y00) = 0 to rule out any pure direct effect so that the exposure has no effect on outcome in absence of mediator; and (M1  −  M0) ≠ 0 indicating that the exposure has an effect on the mediator, i.e. given condition 1 results in M1 ≠ 0.

Similar(54)

Tetrathiafulvalene (TTF), used as the mediator, was also coimmobilized by crosslinking with glutaraldehyde.

The role of positive coping as a potential mediator was also assessed.

The epoxy monolith mediator was also valid for other high-performance resins such as POM and ABS; the bonding strength values were 1.22 ± 0.57 and 2.66 ± 0.74 MPa, respectively.

IL-8, which is in some cases considered a pro-inflammatory mediator, was also strongly associated with IL-1ß, but not with TNF-α and IL-6.

The control treatment, without enzyme and mediator, was also analyzed.

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