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Mediation analysis quantifies how a variable termed mediator influences the effects of an independent variable on a dependent variable (Fig. 4a).
The redox mediator influences the electrochemical response; thus Ru(NH3 63+ and Fe CN 63− gave a similar response and Fe3+ gave the poorest response.
An example of a sequential mediation model is when a treatment (e.g., parent management training) changes the first mediator (e.g., effective discipline), this mediator influences changes in the second mediator in the model (e.g., risk behaviors) and this leads to changes in the treatment outcome (e.g., conduct problems).
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Nocturnal environmental noise may be the most worrying form of noise pollution in terms of its health consequences because of its synergistic direct and indirect (through sleep disturbances acting as a mediator) influence on biological systems.
Together, these findings lend strong support for an important role for the epithelium in fibrogenesis either as a precursor of myofibroblasts or as a mediator influencing the development of myofibroblasts from other cell types.
Certainly, hypoxia-dependent regulation of AP-2 ε expression in both human and murine cells suggests HIF1 to be a conserved mediator influencing AP-2ε gene transcription in mammals.
The balance between pro- and anti-inflammatory mediators influences the survival rate of septic patients.
It is postulated that inflammatory mediators influence cognition via diverse cytokine-mediated interactions between neurons and glial cells.
The mechanisms by which these mediators influence meniscal repair, and their interactions with other factors in the microenvironment, such as mechanical loading, remain to be determined.
When purified CD4+ T cells were cultured in the presence of cell-free breast cancer cell (MCF-7) supernatants (Fig. 1A), a situation mimicking the tumor-bearing condition in which tumor-shed mediators influence the circulating CD4+ T cell repertoire, increase in the percent of dead CD4+ T cell (43.2%) in comparison to control (7.2%) was recorded.
However, it is highly likely that other mechanotransducers or mediators influence set point values.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com