Sentence examples for mediator in the development from inspiring English sources

In addition, PPAR δ has also been shown to be a downstream target of APC/ β-catenin/T-cell factor (TCF -4-mediated TCF -4-mediated acTCF -4-mediated is a key mediatranscriptionallopment of CRC (He et activation

We have recently shown that heparanase-mediated loss of heparan sulfate in the GBM is a possible key mediator in the development of proteinuria and overt diabetic nephropathy.

Thus, the conceptual framework included "information, motivation, and behavioral change" model, with patient engagement as a mediator in the development and assessment of a mobile health application "HeartMapp" for chronic heart failure (CHF) self-management.

The up-regulation of the receptor for advanced glycation end products (RAGE) has been implicated as a major mediator in the development and progression of diabetic nephropathy and hepatic fibrogenesis.

VEGF is a key mediator in the development and maturation of dendritic cells [17].

One known mediator in the development of both glomerulosclerosis and tubulointerstitial fibrosis is transforming growth factor- β1 (TGF-β1)[6]; however, because of its pleiotropic actions, TGF-β may not be an ideal therapeutic target.

Oxidative stress and inflammation are mediators in the development and progression of chronic kidney disease (CKD) and its complications, and they are inseparably linked as each begets and amplifies the other.

However, despite extensive investigation, the precise role of PAF among a lot of inflammatory mediators in the development of sepsis still remains largely unknown.

Epithelial cell-derived CXC chemokines, such as CXCL8 (or interleukin-8), are critical mediators in the development of local inflammation in human IBD [19].

A range of experimental studies have also suggested a pathogenic role for several of these inflammatory mediators in the development and progression of HF [4], [6] [8].

A number of proteins have been implicated as mediators in the development of PTTM.