Sentence examples for mediator function from inspiring English sources

The relationship between important mediator function (high M) and functional importance (low average P-value) is stronger in the case of diabetes.

Biochemical studies show that addition of catalytic amounts of RAD52 results in several fold stimulation of RAD51 recombinase activities by alleviating the inhibitory action of RPA (37, 38), suggesting that mediator function of RAD52 is critical for RAD51-mediated HR (5, 24).

This suggests that the recombination mediator function of Rad52 is required for Rad51 to exert its effect, and it is this function of Rad52 that is required for EGC.

Importantly, rad52-329, a mutation that deletes the C-terminal domain of Rad52 that interacts with Rad51 and permits it to execute its recombination mediator function also has stimulatory effects [38], [39], [40], [41], [42].

This may have important implications with respect to the development of cancer in humans as mutations in RAD51, and BRCA2, which encodes a tumor suppressor protein with a recombination mediator function, confer similar increases in SSA [17], [23], [43], [44], [45], [46], [47].

Abrogating the interaction between Rad51 and Rad52 in rad52-329/rad52-329 homozygotesimilarimilar effects, indicating that translocation formation does not require the mediator function of Rad52, and suggesting that Rad51 cannot inhibit translocation formation if it cannot associate efficiently with DSBs.

Biochemical, molecular, and physiological studies using cancer cell lines or model organisms have established the current paradigm of the Mediator functions.

In terms of functions, initial data suggested that the small mediator functions to activate transcription initiation in vitro, while the large mediator is inactive or acts as a transcription repressor (Taatjes et al. 2002).

The discovery and characterization of multiple, functionally distinct forms of Mediator characterized by the presence or absence of the Cdk8 kinase module have led to new insights into how Mediator functions in both Pol II transcription activation and repression.

Mediator functions as an integrator of transcriptional regulatory activity by interacting with DNA-bound transcription factors and with RNA polymerase II (Pol II) to both activate and repress gene expression.

Thus, Mediator functions to regulate transcription at multiple points in the process of gene expression.