Sentence examples for mediator complex regulates from inspiring English sources

Although the mechanisms by which the Mediator complex regulates transcription are often complicated by the context-dependent regulation, this transcription cofactor complex plays a pivotal role in numerous biological pathways.

The Mediator complex regulates transcription by bridging the general transcriptional machinery with specific transcription factors.

Due to its massive size and complexity, however, the precise molecular mechanism(s) by which the Mediator complex regulates the gene-specific transcription remain poorly understood but are likely to play important functional roles in both normal physiological and pathophysiological states.

MED12, or mediator of RNA polymerase II transcription, subunit 12 homolog of S. cerevisiae, is one of several subunits in the mammalian mediator complex, which regulates RNA polymerase II during mRNA transcription.

The Mediator complex also regulates the release of hindered PolII, enhances the re-initiation and coordinates RNA capping, splicing and polyadenylation (Borggrefe and Yue 2011).

C. albicans is a commensal and opportunistic pathogen of humans and the TLO gene family encodes a subunit of the Mediator complex that regulates transcription and affects a range of virulence factors.

Although the exact function of MED28 is unknown, it has been identified as one of approximately 30 subunits within the mammalian Mediator complex, which regulates activation and repression of RNA polymerase II transcribed genes [ 10- 13].

The R3 methylation status determines the interaction with the SWI/SNF complex and with the Mediator complex to regulate endogenous target genes and cell differentiation in an MAPkinase signalling-dependent manner.

These include chromatin modification, long non-coding RNAs (ncRNAs), microRNAs (miRNAs) and transcription elongation factors that signal to the transcriptional machinery in part through interaction with the Mediator complex to regulate gene expression [11,12].

Furthermore, the Mediator complex not only regulates ERα activity, but also interacts with the cohesin complex to facilitate long-range chromosomal interactions.

The Mediator complex functions to regulate RNAPII-dependent gene expression at multiple stages of transcription including elongation by regulating super-elongation complexes through MED23, MED26 and CDK8 [98,99].