Sentence examples for mediator complex is from inspiring English sources

The mediator complex is involved in transcriptional regulation by mediating the connection between transcription factors and the RNA polymerase II initiation complex 4. MED12 comprises a subunit of a CDK8 submodule of the Mediator, which also contains MED13 and Cyclin C, and regulates the kinase activity of CDK8 5, 6.

Nevertheless, it is generally believed that the Mediator complex is heterogeneous both structurally and functionally.

We have shown that recruitment of the Mediator complex is significantly affected in the absence of H2A.Z.

The Mediator complex is able to bind to various transcription factors and integrates the transcriptional signals to the basal transcription machinery (Malik and Roeder 2010; Taatjes 2010; Conaway and Conaway 2011; Allen and Taatjes 2015).

The Mediator complex is required for polymerase II transcription and acts as a bridge between the polymerase II enzyme and different gene-specific transcription factors.

The Mediator complex is comprised of 24 subunits in Saccharomyces cerevisiae.

The Mediator complex was originally discovered in yeast, but it is conserved in all eukaryotes.

However, in other studies only the large Mediator complex was observed in the biochemical purifications (Wang et al. 2001; Sato et al. 2004).

Furthermore, Lai and colleagues identified ncRNA-activating (ncRNA-a) and revealed that the mediator complex was involved in the establishment or maintenance of chromatin looping between the lncRNA loci and their regulated promoters (Lai et al., 2013).

The human Mediator complex was also found to be extremely dynamic.

It has been shown that some subunits of Mediator complex are necessary for the adipogenic process.