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These factors, called adipokines, involved in the mediation of inflammatory diseases and obesity [ 5, 6].
The mechanism of CD13 in cGVHD pathogenesis remains unclear but may involve mediation of inflammatory responses by T cells.
TNF- α, interleukin-6 (IL-6), and interleukin-10 (IL-10) play an important role in mediation of inflammatory processes.
It is a major player in the mediation of inflammatory responses and inhibition of nerve fiber growth and tissue repair processes [ 24].
TLR4, which acts as the lipopolysaccharide (LPS) receptor [ 46], is implicated in the mediation of inflammatory response to gram-negative bacteria [ 47].
Consequently, these models have been important in investigating the roles of FLS in the mediation of inflammatory bone loss [ 8- 11].
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Whole brain mediation analysis was next performed using our FDG-PET imaging data to identify the neural mediators of inflammatory effects on diastolic blood pressure.
Several caspases have been associated with inflammatory diseases and mediation of pro-inflammatory cytokines [41].
Advanced glycation endproducts (AGEs) are primarily known as a complication in diabetic patients through their mediation of the inflammatory response.
In addition, TNF-α also plays a crucial role in mediation of the inflammatory process in adipose tissue [29].
Tumor necrosis factor-alpha (TNF-α), a proinflammatory cytokine, plays a critical role in mediation of the inflammatory synovitis, cartilage matrix degradation, and bony erosions in RA [ 4].
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