EHDs possess several domains that could potentially mediate various functions.
Considering that thrombin was shown to mediate various functions unrelated to blood clotting, either directly by cleavage of protease-activated receptors (PARs) or indirectly by cleaving osteopontin (OPN) on stroma cells, the role of PAR1 and PAR4 antagonists as well as treatment with cleaved form of OPN (tcOPN) were tested.
FCGRs can mediate various functions, such as antibody-dependent cellular cytotoxicity and phagocytosis.
Growth-related oncogene- (GRO-) β is a member of the CXC chemokine family, which may mediate various functions, such as attracting neutrophils to sites of inflammation, regulating angiogenesis, and participating in tumorigenesis and progression.
Boswellic acids from Boswellia sp. resins have been suggested to be a major compound in mediating various biological functions including anti-inflammatory and anti-cancer activities.
The substrates of the 26S proteasome include proteins mediating various cellular functions such as transcription, stress response, cell cycle regulation, oncogenesis, ribosome biogenesis, cellular differentiation, and DNA repair (Ciechanover and Schwartz, 1998).
It was recently revealed that the so-called "E-network" mediates various functions, including sense of self, resting state, ToM, memory recall, and reasoning [16].
Chemokines are produced by macrophages, lymphocytes, neutrophils and dendritic cells and mediate various functions of these cells, including recruitment of other cells [47], [48].
Bmpr1a mediates various functions during development of urogenital organs derived from urogenital sinus (19, 20).
The benthic macrofauna in mangrove forests are important contributors to ecological functions, mediating various sedimentary properties.
