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Cubilin was shown to be an endocytic receptor for apolipoprotein A-I (apoA-I /high density lipoprotein (HDL), mediapoA-I /high of Hdensityhe kidney and visceralipoproteinum [ 26, 27].
It has recently been discovered that megalin, a large multiligand endocytic receptor of the low density lipoprotein receptor family, is capable of binding and mediating uptake of the soluble form of the GPI-anchored folate receptor Folr1, providing yet another pathway for the cellular internalization of folate [ 9].
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The RhoA-mediated mechanism is able to mediate uptake of both gold particles, ricin-HRP and HRP.
Interestingly, hTIM-1 can mediate uptake of viruses independent of the glycoproteins (Moller-Tank et al., 2013; Jemielity et al., 2013; Takada et al., 1997).
The two major renal transporter proteins identified to date are the high affinity transporter URAT1 (SLC22A12) that mediates uptake of urate from the urine into the renal proximal tubular cell, and GLUT9 (SLC2A9/URATv1) which is a voltage-sensitive uniporter that mediates the export of UA from the proximal tubular cell into the circulation[118, 119].
GTL-2 localizes to the basal membrane of the excretory cell, suggesting that it mediates uptake of Mg2+ from the pseudocoelomic fluid.
Taken together, these data corroborate the findings of the adhesion assays and gentamicin protection assays and demonstrate that CEACAM1 can mediate uptake of Opa protein-negative meningococci.
In relation to this finding, micro-array data also show >2-fold suppression of Lipg (endothelial lipase) that mediates uptake of HDL particles and promotes ApoAI mediated cholesterol efflux [31].
The particularity of Gap1 is that it can mediate uptake of all protein amino acids as well as citrulline, ornithine, γ-aminobutyrate (GABA), β-alanine and even D-isomers such as D-histidine.
The reason for this variation is not known, but it is possible that cones differentially express the nucleolin cell-surface protein known to mediate uptake of the nanoparticles [12]; alternatively, heterogeneity in the response to the injection insult may affect NMP expression/uptake.
A similar strategy has been demonstrated with the ferric aerobactin receptor (IutA) mediated uptake of aerobactin by V. parahaemolyticus [ 26].
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