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These transporters are ATP-dependent drug efflux pumps mediating transport of endogenous and xenobiotic substances.
However, in contrast to porins mediating transport across the outer membrane by passive diffusion, TBDT transporters employ a unique energizing mechanism utilizing the TonB complex and the proton-motive force of the cytoplasmic membrane.
FcRn also contributes to passive immunity by mediating transport of IgG from mother to fetus (human) or newborn (rodents), and may translocate IgG over mucosal surfaces.
Thus, the PEXEL/VTS motif is functional in P. berghei, mediating transport to the erythrocyte, but the motif functions only with an upstream signal/hydrophobic sequence.
Overall these findings implied that two distinct connections between EP islands existed: the first being simple, tubular connections possibly mediating transport of cellular material between two cells (type I); and the second being complex, tubular connections facilitating migration of entire cells between multi-cellular EP islands (type II).
The first type of EP bridge may be functionally similar to cytonemes and TNTs by possibly mediating transport of cellular material between cells, while the second type of EP bridge is distinct in function compared to cytonemes and TNTs by facilitating the migration of entire cells between EP masses.
Similar(48)
Transport of lactate, pyruvate, and other monocarboxylates across the sarcolemma of skeletal and cardiac myocytes occurs via passive diffusion and by monocarboxylate transporter (MCT) mediated transport.
Endogenous compounds and drugs may cross BBB by different mechanisms such as passive diffusion, carrier-mediated transport (like GLUT1 mediated transport), endocytosis, and active transport [ 45– 52].
I) Shows receptor-mediated transport, II) demonstrates non-specific uptake through adsorption-mediated transport, and III) displays carrier-mediated transport.
Higher absorptive transport indicated role of carrier mediated transport.
These proteins are believed to mediate transport of different substrates across plant PMs29,30,31.
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