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Module 7 was enriched in genes mediating transmission of nerve impulse (P = 2.0E-4) and one of its major hub genes is Cbp53E.
With its prominent links to the actin cytoskeleton, vinculin is a major candidate for mediating transmission of signals between the cell matrix and the cytoskeleton, and there is accumulating evidence that vinculin regulates this process.
In more recent times it has been hypothesized that αsyn itself may be a critical factor in mediating transmission of disease pathology from one brain area to another.
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Potentiation of synaptic transmission is often mediated by a enhanced function of AMPA receptor mediated transmission relative to NMDA receptor mediated transmission [23] [24].
Long-term therapeutic and unrestricted prophylactic use of vancomycin has given rise to VRE which in turn may lead to the emergence of vancomycin-resistant S. aureus (VRSA) through plasmid mediated transmission.
More than 2 billion people in tropical and sub-tropical regions have limited access to safe water and improved sanitation, placing them at risk for contracting a variety of infectious pathogens, yet the social and environmental factors that mediate transmission of pathogens between people and the environment are poorly understood, particularly in the context of environmental change.
Cx43, which composes gap junction channels (GJCs), mediates transmission and dispersion growth/suppressive factors and reveals the contact spots between astrocytes [19, 20].
Among these antigens are a number that elicit humoral responses which mediate transmission blocking immunity.
Besides VCL binding, PXN interacts with SRC and CRK family members [114], which leads to proliferation and differentiation processes in fibroblasts through the MAPK pathway or regulates the formation of physical links between the cytoskeleton and integrin proteins that mediate transmission of contraction forces [115].
There is evidence, in fact, that besides lympho-reticular cells [ 11, 44, 45] also mononuclear phagocytic cells [ 46, 47] support replication of prions and may mediate transmission of infection from periphery to central nervous system.
Vesicle fusion contributes to the maintenance of synapses in the nervous system by mediating synaptic transmission, release of neurotrophic factors, and trafficking of membrane receptors.
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