Sentence examples for mediating this increase from inspiring English sources

Indeed, inhibition of this response to 4-HPR by FB1 and myriocin indicates a stimulatory action on the de novo synthesis pathways of ceramide production as the mechanism mediating this increase in ceramide levels.

Although the precise mechanisms mediating this increase are still topics of active investigation, numerous studies suggest that at least some of the regulatory elements for the reactive response lie within a 2.2 kb fragment of the 5′ region of the gene.

Further, we identify a key role for Rac1 signalling in mediating this increased N-Cadherin expression.

Induction of citrullination by EGF has not previously been reported and our lab is currently working to understand the up- and downstream signaling pathways that mediate this increase in PAD2 and its catalytic activity.

While the SVZ expands we do not fully understand the mechanisms that mediate this increase.

Subsequent studies therefore sought to identify the gene sequences that are required to mediate this increase in transcription rate.

Thus, one attractive possibility is that a developmental decrease in retinal DA concentrations, similar to that observed in adult GLE offspring, mediated this increased neurogenesis.

LSCC cells harbouring wild-type p53 were significantly radiosensitised by Nutlin-3 (P<0.0001; log-rank scale), and displayed increased cell cycle arrest and significantly increased senescence (P<0.001) in the absence of increased apoptosis; thus, our data suggest that senescence may mediate this increased radiosensitivity.

However, the mechanism mediating this increased risk and the potential involvement of radiation exposure have yet to be elucidated.

The amount of fascin required to mediate this transition increases nonlinearly with [Arp2/3], saturating above 40 nM Arp2/3, (the blue curve marks the approximate boundary between the two regions).

It has been unclear whether driver experience with ACC mediates this increase.