Sentence examples for mediating these actions from inspiring English sources

However, the endogenous molecular pathways mediating these actions are poorly understood.

At the molecular level, DHEA was shown to improve glucose uptake [ 33] and reduce the formation of reactive oxygen species [ 34], however, the putative roles of Sirt1 or TXNIP in mediating these actions are not known.

To confirm that carbachol was mediating these actions via mAChR activation, MIN6 cells were treated with carbachol, or the mAChR-selective agonist methacholine, in the absence and presence of the mAChR antagonist atropine.

Recently, Gonzales et al. demonstrated that, in vitro and in mouse xenografts, the local delivery of capsazepine decreases cellular duplication rate and reverses the growth of oral squamous carcinoma cells, inducing the production of reactive oxygen species and apoptosis, and mediating these actions independently from TRPV1 activation.

While the existence of progesterone-triggered non-genomic signaling is now relatively well accepted [ 2, 3], the receptors mediating these actions, as well as the physiologic relevance of these extra-nuclear signals, continue to be a matter of intense debate [ 4, 5].

Also, the PPAR-response elements were not identified on FAT/CD36 gene [ 42], and PPARα may need specific coactivators such as PGC1α to mediate these actions [ 43].

To corroborate this further, we next investigated whether the A2MG receptor, the low-density lipoprotein receptor-related protein (LRP) 1, mediated these protective actions.

We established a cell model with which to screen the rapid non-genomic activities of estrogenic compounds using cells naturally expressing high levels of a membrane form of ER-αthought to mediate these nongenomic actions.

However, the mechanisms mediating the actions of ethanol on neurons remain elusive.

We therefore explored which, if any, of these kinases is involved in mediating the action of S100A7 on sAPPα release.

In those studies, GABAA receptor antagonism blocked the anxiolytic-like effect of the Montanoa extracts, suggesting that the GABAergic system mediates the actions of these plants on the central nervous system.