For instance, Zn2+ is an essential co-factor for MTF-1, a transcription factor that binds to metal response elements in the promoter region of MT genes mediating their response to Zn2+ (Andrews, 2001; Wimmer et al., 2005).
The binding of ABA to FCA and ABAP1 is apparently a further example of newly emerging mechanisms by which plant growth regulators mediate their responses.
Our previous studies demonstrated that the increase in Ca influx observed within minutes of E2, BPA, and NP application is strictly dependent on mER-α and mediated by L-type voltage-gated Ca channels; EP, PP, and OP likely use a similar cellular machinery to mediate their responses.
Both systems converge and mediate their response through a cascade of phosphorylation reactions of LuxU (AWOD_I_0921) and LuxO (AWOD_I_0920).
This was a key finding demonstrating that the stromal environment of the tumor cells could mediate their response to drug treatment.
Combination therapy has been shown to provide enhanced antitumour activity; however, the downstream signalling to explain how these drugs mediate their response is not clearly understood.
The introduction of HPV 16 into these cells not only increased their relative levels of proliferation, but also mediated their response to PAC, with lower dosages actually stimulating proliferation of CAL 27-TF16 cells.
The importance of HIF in mediating their transcriptional responses to relative physiological oxygen tensions is now well described, with the oxygen-sensitive hydroxylase enzymes critical in this response.
Current studies have indicated that different types of IFNs may substantially overlap in mediating their innate immune response by activating the same set of ISGs.
Degradation of HS disintegrates the supramolecular structure of the subendothelial basal lamina, consequently facilitating trans-endothelial migration of neutrophils and activated lymphocytes, thereby mediating their extravasation during immune responses [10], [11], [15], [23], [24], [25].
