Platelet secretion is undoubtedly of pivotal importance for regulating not only canonical platelet functions, but also mediating their impact on other cells, and understanding platelet secretion may have consequences reaching far beyond the 'platelet field'.
Moreover, the emphasis it placed on estimating average CSR effects in a given setting diverted attention from the heterogeneity of these effects and the conditions that mediated their impact, limiting its external validity.
These variants may mediate their impact through mechanisms other than altering the expression of anchors.
It is more difficult for healthcare professionals to mediate their impact on other aspects of care that might re-enact abuse.
The totality of the evidence for these loci therefore indicates that their effect on HDL-C is primarily mediated by their impact on HDL particle size.
The data also indicated that the anabolic effects of bortezomib and PIs may have been mediated by their impact on the osteocytes rather than on osteoblasts.
Our present findings suggest that such genetic influence on individual differences in perceptual switch rate might be mediated by their impact on the development and maturation of the SPL.
Our work has further clarified the way in which these factors impact on an individual's QoL, as illustrated in Figure 2. It appears that the impact of personal and social, NHS response (treatment) and disease state factors on QoL are mediated by their impact on a person's emotional, physical and social functioning.
A realist approach to theory building was used, constructed around the mechanisms that characterise integration, their impacts, and mediating, contextual influences.
Recent research and theory suggest that executive function and self-regulation may play a central role in moderating or mediating the impacts of poverty-related stressors and risks on a number of important outcomes across learning, behavior, and health.
