Sentence examples for mediating the transition from inspiring English sources

Thus, Rb loss acts as a switch mediating the transition between premalignant lesions and cancer through DDR modulation.

By virtue of the uncovered role of SphK1 in mediating the transition from androgen-dependent to androgen refractory state, the pharmacological inhibition of SphK1 and its downstream signaling could represent a viable strategy to prevent or delay the progression to hormone-refractory prostate cancer.

Unfortunately, the mechanisms or predispositions mediating the transition from CARS to immunoparalysis are currently unknown.

These signals mediating the transition of normal to reactive fibroblasts are still not completely defined.

Hd3a regulates photosensitivity in rice by mediating the transition from vegetative to reproductive growth (Tamaki et al. 2007).

Frangogiannis speculated that transforming growth factor-β acts as a "master switch" mediating the transition from inflammation to fibrosis, activating Smad-dependent and -independent pathways (12).

We show that auto-regulation creates a positive feedback, which mediates the transition from early to late stages of regulation.

TGF-β can promote the synthesis of various cytokines and growth factors that are involved in the formation of cardiac fibrosis and mediate the transition from acute inflammation to fibrosis in ischemic heart disease [45].

Rudolph Hermann Lotze (1817 1881) mediated the transition from the exuberance of German idealism, in the first half of the nineteenth century, to the sober, scholarly and scientific ethos that came to prevail in the second half.

Malcolm Schofield (1991: 103) has argued that this development "mediates the transition from republicanism to natural law theory," so bequeathing a crucial resource to early modern thinkers who sought to construct new versions of the latter; under the emperors, Hellenistic theories of monarchy would also gain a new lease on life.

Accordingly, we suggest that several growth factors mediate the transition from the tumor supportive MSC to the tumor supportive TAF.