Sentence examples for mediating the systemic from inspiring English sources

To combat this problem, the body has developed a regulatory system specifically designed at mediating the systemic response to obesity, utilizing free fatty acids (FFAs) and their metabolites as nutrient messengers to signal adaptations from peripheral tissues.

Many vasoactive chemicals have been hypothesized as being involved in mediating the systemic hemodynamic changes, including atrial natriuretic factor, prostacyclin, thromboxane A2, and endotoxin.

Even though epithelial cells do not appear to be able to generate new virions under normal conditions, they can function as a virus transmission mechanism to permissive cells through HIV contact and transfer, thus mediating the systemic spread [ 105].

The identity of the circulating factors, such as cytokines and metabolites, and mechanisms mediating the systemic response of cardiac specific mIGF-1/SIRT1 remain to be addressed (Fig. 7).

They have only been identified in inflamed skin where they promote wound repair and mediate the systemic pro-inflammatory response that is seen after stimulation with Toll-like receptor 7 (TLR7) agonists (Gregorio et al., 2010).

As blood insulin concentration inversely mediates the systemic insulin sensitivity, insulin sensitivity is greater in the GHR-KO mouse than in its littermate control [ Liu et al., 2004].

Circulating mtDNA from tissue injury was recently found to be essential to mediate the systemic inflammatory response and target organ damage [ 16].

The expression of eNOS may be induced by calcium-dependent binding of calmodulin via proinflammatory cytokines or by serine phosphorylation through the Akt pathway [ 19]. eNOS may mediate the systemic microvascular leak of VILI [ 20].

Other workers in our research group have found that eNOS but not inducible nitric oxide synthase may mediate the systemic microvascular leak in a rat model of VILI [ 20].

Frischmuth et al. [ 54] demonstrated that although the OW begomoviruses will mediate the systemic movement of the DNA-A components of NW viruses, the NW viruses cannot support the movement of the DNA-A components of OW begomoviruses - highlighting a further divergence between the NW and OW begomoviruses [ 55].

Preeclampsia (PE) occurs as a result placental hypoxia-induced oxidative and endoplasmic reticulum stress, and is associated with the activation of hypoxia inducible factor-1α (HIF-1α) and apoptotic CHOP pathways with the consequential shedding of syncytiotrophoblast microvesicles which may be central in mediating the maternal systemic immune response.