Sentence examples for mediating the suppressive from inspiring English sources
Ca2+ is an essential component for efficient elaboration of LPS- and LTA-mediated cytokine response but plays a differential role in mediating the suppressive effects of low pH stress.
These data, those of previous studies, and recent preliminary findings support involvement of dopamine D2, but not D1 or D3 receptors in mediating the suppressive effect of TA-0910 on alcohol intake of P rats.
Many studies suggest the importance of regulatory cytokines IL-10 and TGF-β in mediating the suppressive activity of Tregs [13].
Initial cell seeding density may be a critical factor in mediating the suppressive effects of CFTR on inflammation as only at a certain density (1×105 cells/well) did we observe the reduction in NF-κB activity.
The EP2 receptor was further implicated in mediating the suppressive effects of PGE2, as siRNA directed against Ptger2, but not scrambled or Ptger4 siRNA, prevented PGE2-induced decreases in Sost.
To define which receptor(s) are responsible for mediating the suppressive effects of PGE2 upon Sost, UMR 106.01 cells were treated with 5 µM PGE2 in the presence of antagonists of protein kinase A (H-89, 2.5 µM) or phospolipase C (U73122, 10 µM) for 3 hours, after which time total RNA was collected and analyzed for Sost levels.
In conclusion, we report for the first time the existence of a miRNA-regulated mechanism in human islet cells that mediates the suppressive effects of high glucose on insulin biosynthesis.
Under ordinary conditions, STAT3 mediates the suppressive effect of IL6 on hepatic glucose production [ 32].
As reported, STAT5 mediated the suppressive effect of IL-2 on TH17 differentiation (Supplementary information, Figure S3A and S3B).
These molecules are reported to act synergistically to mediate the suppressive effects of MSCs in the inflammatory microenvironment.
Overexpression of Egr-1 potentiated, whereas overexpression of Sp1 alleviated, the suppressive effect of IL-1 on the PPARγ promoter, suggesting that Egr-1 may mediate the suppressive effect of IL-1.
