Sentence examples for mediating the stimulation from inspiring English sources

MAP kinases, such as p38, JNK, or ERK, are known to be crucial signaling pathways mediating the stimulation of inflammatory mediators (48, 49), with the p38MAPKα pathway being critical for normal inflammatory responses in vivo (50).

Taken together, these results not only confirm that the inhibitory effect of Nab2 was selective for Egr-1-dependent transcriptional responses, but also serve to further underline the essential role of endogenous Egr-1 in mediating the stimulation of collagen gene expression and myofibroblasts differentiation induced by TGF-β.

Another possible explanation for the inhibitory effect of the GR on sPLA2-IIA promoter activity is the competition with PXR (mediating the stimulation by micromolar concentrations of oxysterols) or LXRβ (involved in the regulation of basal promoter activity) for the recruitment of a common coactivator.

However, the post-receptor pathways mediating the stimulation of transvascular albumin transport by ANP are unknown.

Several signalling pathways may be involved in mediating the stimulation of cell migration and invasion exerted through these receptors.

Calmodulin (CaM), by mediating the stimulation of the activity of two adenylyl cyclases (ACs), plays a key role in integrating the cAMP and Ca2+ signaling systems.

Using these selective ER subtype agonists, we show that ERβ mediates the stimulation of calcium oscillations in neurons derived from mouse and human ES cells, which demonstrates that these neurons might be a useful cell based model to study the role of ERs and the nongenomic mechanisms of estrogens.

In normal hepatocytes, L-FABP mediates the stimulation of DNA synthesis and cell growth by long-chain fatty acids.

They activate the peroxisome proliferator-activated receptor (PPAR), mainly PPAR-α, which mediates the stimulation of the fatty acid β-oxidation [ 10– 13].

The stimulatory effects of SST were reduced by gallein pre-incubation, which confirmed that the Gβγ liberated from the Gi-coupled SST receptor mediated the stimulation.

The promoter region of human OPG contains various putative transcription factor binding sites that may mediate the stimulation of OPG expression by different calciotropic factors [ 7].