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To determine which ER subtype was responsible for mediating the rapid stimulatory effect of E2 on [Ca2+]i oscillations, the cells were treated with ERα or ERβ-selective agonists.
Taken together, these data reveal a critical role for mTORC1 signaling in mediating the rapid growth and proliferation of erythroid progenitors during stress erythropoiesis.
SRF is a transcription factor, a phylogenetically conserved nuclear protein, mediating the rapid transcriptional response to extracellular stimuli, e.g., growth and differentiation signals (Arsenian et al. 1998).
The ubiquitin-proteasome system appears to play an important role in mediating the rapid turnover of these proteins (Eide et al., 2005).
Interactions of estradiol with neurotransmitter receptors, such as GABA, NMDA, and dopamine receptors, have been implicated in mediating the rapid regulation of lordosis in female rats [ 123].
Further supporting the role of GPER in mediating this estrogen-stimulated effect, the GPER-selective ligand was equally efficacious to estrogen in mediating the rapid translocation.
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Thus, this intracellular vesicular system mediates the rapid mobilization and secretion of preformed IL-4 by activated eosinophils.
They are designed to mediate the rapid and efficient transmission of signals from the presynaptic bouton of one neuron to the postsynaptic plasma membrane of a second neuron.
Voltage-gated Na+ channels mediate the rapid upstroke of the action potential in excitable tissues.
Our data is consistent with the observation that ERβ mediates the rapid phosphorylation of CREB in OVX mice [86].
The rapid stimulation of SphK1 was dependent on activation of the PI3K/Akt signaling, which has been shown to mediate the rapid effects of androgens [39], [40].
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