Sentence examples for mediating the pathogenic from inspiring English sources
These observations suggest a potential role for autophagy in mediating the pathogenic actions of LRRK2 mutations.
Our study reveals a potential role for alterations in autophagy and neuritic morphology in mediating the pathogenic effects of LRRK2 mutations in vivo.
In addition, we have also demonstrated that a Burkholderia-specific mechanism mediating the pathogenic effect in C. elegans requires proliferating B. pseudomallei to continuously produce toxins to mediate complete killing.
The observation that administration of blocking antibodies to HMGB1 protected mice from lethal septicemia strongly suggests that the engagement of cell surface receptors such as RAGE by HMGB1 might play an important role in mediating the pathogenic effects of HMGB1 [ 6].
These proinflammatroy cytokines are likely to mediate the pathogenic potential of Th17 cells.
ROS produced by protein glycation and glucose oxidation mediates the pathogenic effects of high glucose.
These signaling mechanisms are widely assumed to be functional in cells chronically exposed to TNF-α and to mediate the pathogenic effects of TNF-α in chronic inflammation.
Although previous studies had shown the importance of IL-23 in mediating the development of pathogenic CD4+ T-cell population that produces differential IL-17 (a cytokine associated with higher pathology in schistosomiasis), we found no association between the risk of schistosomiasis-associated IRIS and magnitude of change in CD4+ cell counts or decrease in HIV viral load.
This might represent a common persistent pathogenic factor mediating the initial stage of the atherosclerosis as well as the progression to complicated plaque in diabetic patients [ 23].
This observation suggests an alternative pathogenic factor mediating the increased cardiovascular risk in patients with OSA and MS, other than that due to IR.
In contrast, in PIA antibodies to citrullinated proteins are not evoked and there is no evidence for pathogenic antibodies mediating the disease, unlike in the collagen-induced arthritis model.
