Sentence examples for mediating the pathogenesis from inspiring English sources
The presence of human immunodeficiency virus type 1 (HIV-1) in the brain is believed to be responsible for mediating the pathogenesis of neurological abnormalities through the viral toxins gp120 and Tat.
In light of the central role that TGF-ß plays in mediating the pathogenesis of fibrosis, we sought to examine the possibility that it might modulate the expression of PPAR-γ, and that activated TGF-ß signaling could account for impaired PPAR-γ expression seen in SSc.
Abundant evidence indicates that PDGF and its receptors are important in mediating the pathogenesis of airway and interstitial lung fibrosis [ 25].
IL-10 inhibits IL-17 and RORγt expression in macrophages and suppresses macrophages toward the proinflammatory M1 phenotype, which is important for the role of IL-10 in mediating the pathogenesis of CIA.
The precise mechanisms involved in regulation of persistent synovial infiltration and invasion are unclear, but high levels of TNF-α may be crucial in mediating the pathogenesis of IA.
To conduct basic studies that further define the mechanisms mediating the pathogenesis of severe asthma, particularly those phenotypes characterized by late onset, obesity, steroid-unresponsiveness or non-inflammatory pathways.
IL-1β is also shown to mediate the pathogenesis of UC [ 30].
Type IV secretion systems have been demonstrated to be important for virulence in other microorganisms and are thus likely to help mediate the pathogenesis of A. baumannii [ 23].
Moreover, oxidative stress has been shown to mediate the pathogenesis of neurodegenerative diseases, including PD [ 6], AD [ 32], and cerebrovascular disorders such as stroke [ 31].
It is important to propose that IL-17 can induce IL-22 or that these cytokines may act together to mediate the pathogenesis of AIA.
For example, dietary obesity was found to induce NADPH oxidase-associated oxidative stress in rat brain [ 84], indicating that brain oxidative stress could potentially mediate the pathogenesis of overnutrition-related metabolic diseases.
