Sentence examples for mediating the multiple from inspiring English sources

We have investigated the potential role of Wnt7b in mediating the multiple functions of Ihh signaling during endochondral bone development.

How CXCR7 mediates the multiple functions has remained a mystery.

miR-23b-3p was downregulated in human colon cancer, which regulates FZD7 or MAP3k1 to mediate the multiple steps of metastasis in vivo.

TrkA specifically mediates the multiple effects of the nerve growth factor (NGF) signaling through receptor autophosphorylation and downstream induction of the mitogen-activated protein kinase (MAPK) and protein kinase B (PKB/AKT) pathways [ 1].

Taken together, our studies have comprehensively analyzed the protein expression profiles of ERβ1 across multiple breast cancer sub-types and demonstrated critical roles for this receptor in mediating the effectiveness of multiple therapeutic treatment strategies for breast cancer patients that are related in part to the presence and absence of ERα expression.

Recent studies have reported that miRNA-205 is frequently deregulated in multiple tumour entities and involved in various crucial pathways, such as cell proliferation, apoptosis and angiogenesis, by mediating the expression of multiple oncogenes (figure 7).

Decades of research in this disorder have identified abnormalities in neurotransmitter systems, and there is a growing appreciation that signal transduction pathways play a crucial role in mediating the dysfunction in multiple neural network systems and physiological processes (Bhalla and Iyengar [2007]).

These observations further argue against the solitary regulation of individual genes by T-Ag, and rather support a broader role for this oncogene in mediating the expression of multiple targets that cumulatively impact the metastatic phenotype in CRC.

MCL-1 is a compelling cancer target in its own right, having been implicated in mediating the survival of multiple tumor types.

Thus, the data show that the signalling mechanisms mediating the effects of neurotensin involve multiple pathways and are cell-dependent.

If there is a creative class, in Richard Florida's phrase, there is also emerging what might be called a fusion class: people positioned to mediate among the multiple societies that claim them.