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We used the same chemical inhibitor approach taken with EpRas to determine what pathway was mediating the migration of PC3 cells.
There is however evidence that NP-1 [ 7] and VEGFR1 are also involved in VEGF signaling [ 31] and may be involved in mediating the migration process.
The chemokine and chemokine receptor families play critical roles in both the healthy and diseased organism mediating the migration of cells.
These findings are strongly suggestive of a role of JAML in mediating the migration of monocytes and CD8 T cells across the BBB.
It forms a noncovalently linked heterodimer with the common β-subunit CD18 and binds to various adhesion molecules in the endothelial cells and extracellular matrix, therefore mediating the migration and adhesion of cells during monocyte differentiation [ 11, 26].
Thus, the contribution of inflammatory chemokines to the pathogenesis of multiple sclerosis and EAE by mediating the migration of circulating leucocytes across the blood brain barrier into the CNS requires the existence of a putative transport mechanism for inflammatory chemokines from the abluminal to the luminal side of the blood brain barrier endothelium.
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Since TNF-α was shown to influence the migration of various kinds of cells [30], [31], [32], [33], we next tested whether TNF-α released by reactive astrocytes was involved in mediating the migration-promoting activity of OECs.
The present study indicates that collagen fragments can mediate the migration of bone marrow stromal cells.
In contrast, less is known about how the geometric cues mediate the migration dynamics of cells.
Integrin αvβ3 is a molecule which mediates the migration of endothelial cells through the basement membrane during blood vessel formation.
Recent literature indicates that CD177 mediates the migration of neutrophils across endothelial cells via interactions with proteinase 3 (Kuckleburg et al., 2012; Kuckleburg and Newman, 2013) and PECAM-1 (CD31) (Sachs et al., 2007; Bayat et al., 2010), as well as the degranulation and superoxide generation in a Mac-1-dependent manner (Jerke et al., 2011).
More suggestions(15)
mediating the impact
mediating the semantization
mediating the effect
mediating the dispute
mediating the inflammation
mediating the activation
mediating the journey
mediating the building
mediating the conflict
mediating the production
mediating the initiation
mediating the response
mediating the inhibition
mediating the function
mediating the failure
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