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Therefore, under the hypothesis that there is an underlying dynamics (i.e., fluctuation profile) for the three-dimensional (3-D) structure of a protein, which is crucial for the function, our metric dfi quantifies the contribution of each position to this functional dynamics and is designed to capture the key residues mediating the function through the residue interaction dynamics.
We have found a widespread role for FGF signaling in regulating the expression of genes mediating the function of the Spemann organizer.
Thus, besides the roles in regulating microgametogenesis and pollen tube guidance, AtPV42a and AtPV42b might also play a role in mediating the function of SnRK1 complexes in post-fertilization processes, such as seed development.
Argonaute proteins are important for mediating the function of miRNAs.
We then validated the effects of ADCY5 on mediating the function of miR-17 in senescence.
Previous studies demonstrated that MAPK and PI3K pathways are involved in mediating the function of a neudesin, a mouse homologue of GIG47.
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Signal Transducer and Activator of Transcription (STAT) 3 is activated in response to cytokines and growth factors and it has been recently identified as a novel signal transducer for TrkA, mediating the functions of NGF in nervous system.
Together, our findings suggest that Pak2 is the primary effector for mediating the functions of Rac and Cdc42 in T cell development and activation.
There are many genes in the region of the rs646776 locus (Figure S3), and CELSR2, PSRC1 and SORT1 genes have been suggested to mediate the function of this SNP (or functional SNPs in LD [11], [18] [20].
Protein interactions mediate the function of biological systems, where the evolution of interactions is important to understand the functional mechanism in act (Juan et al. 2008; Lovell and Robertson 2010).
Cheng, X. et al. Pacer mediates the function of class III PI3K and HOPS complexes in autophagosome maturation by engaging Stx17.
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