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Fig. 3: METTL3 regulates STAT3/KLF4/SOX2 pathway by mediating the expression of JAK2 and SOCS3.
Further study shows that METTL3 regulates JAK2 STAT3 pathway by mediating the expression SOCS3 (a negative regulator of JAK2 STAT3) and JAK2 in an m6A-YTHDF1/YTHDF2-dependent manner.
Since LHX6 was found to promote normal palate development through mediating cell cycle33, it is hypothesized that LHX6 may overcome the resistance to EGFR-TKIs in NSCLC through mediating the expression of cell cycle-, andproliferation-associatedn-associated genes.
Our data suggest that ATPR could inhibit the proliferation and induce differentiation of MCF-7 cells via mediating the expression of RRIG1.
Detailed information about the pathway corresponding genes are given in Supplementary Table 2. Candidate transcription factors mediating the expression of CNOT-dependent target genes were suggested by the TRRUST (transcriptional regulatory relationships unravelled by sentence-based text-mining) database45 and include CIITA as well as members of the RFX transcription factor family (Fig. 2D).
Here we demonstrated that the histone demethylases KDM4A and KDM4C played an indispensable but independent role in mediating the expression of fetal liver kinase (Flk)1 and VE-cadherin, respectively, and thereby the transition of mouse ESCs (mESCs) to endothelial cells.
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Furthermore, we show that the sustained network activation of the LA mediates the expression of the ILSCm-induced innate fear-related defensive behaviours.
Sharf, R., Sarhan, M. & Dileone, R. J. Orexin mediates the expression of precipitated morphine withdrawal and concurrent activation of the nucleus accumbens shell.
However, the DcuS/DcuR TCS could not produce a signal strong enough to mediate the expression of the gfp gene responding fumarate concentration.
The human interferon gamma (hIFNγ) gene was used as a fusion partner to mediate the expression of heterologous proteins and the effect of the fusion partner length on the expression of the heterologous protein was researched.
One hour after training, pleural ganglia from the trained and untrained sides of the body were harvested; these ganglia contain the sensory nociceptors which help mediate the expression of long-term sensitization memory.
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mediated the expression
mediating the impact
mediating the semantization
mediating the effect
mediating the dispute
mediating the inflammation
mediating the activation
mediating the journey
mediating the building
mediating the conflict
mediating the production
mediating the initiation
mediating the response
mediating the inhibition
mediating the function
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