Sentence examples for mediating the efflux from inspiring English sources
The CmeABC multidrug efflux pump, which belongs to the resistance-nodulation-division (RND) family, recognizes and extrudes a broad range of antimicrobial agents and is essential for Campylobacter jejuni colonization of the animal intestinal tract by mediating the efflux of bile acids.
The role of Kv1.3 and KCa3.1 in mediating the efflux of K+ in order to maintain the hyperpolarization of the cell membrane is well explained in the literature.
Hoeberichts et al. [ 33] observed that glucose-induced cell death correlates with K+ and nucleotides effluxes and can be explained if H2O2 activates plasma membrane proteins mediating the efflux of these small molecules.
The lack of cross-resistance to taxanes in MCF-7DOX cells also support the previous finding that ABCC1 may be more efficient in mediating the efflux of doxorubicin, but not taxane [ 19, 28].
This Na+ extrusion system, however, seems not to depend on the plasma membrane Na+/K+-ATPase that mediates the efflux 3Na+ and the influx 2 K+, which is ubiquitous in animal cells (Jeschke [1984]).
Since ABC transporter family utilize the energy of ATP hydrolysis to transport various small molecules across cellular membranes, it seems that ABC transporters may mainly mediate the efflux of erythromycin rather than import molecules associated with erythromycin synthesis.
ASCT1 not only mediates the efflux of glutamate from the neuron into the synaptic junction via Calcium-independent release, but also mediates the efflux of L-serine from glial cells and its uptake by neurons [ 17- 19].
In the presence of bile salts, ABCB4 located in nonraft membranes mediates the efflux of phospholipids, preferentially phosphatidylcholine.
ABCA1 is a lipid transporter that mediates the efflux of cellular cholesterol to lipid-free apolipoprotein A-I [ 49].
ABCG2 is expressed in the plasma membranes of a variety of tissues, including placenta, pharynx, bladder, brain, and intestine, and mediates the efflux of xenobiotics.
ABC transporters, for example, Pgp membrane efflux pumps, are expressed in normal tissues including intestinal epithelia, liver, renal tubules, and lung, where they mediate the efflux of toxins and drugs (Han and Zhang, 2004; Leslie et al, 2005).
