Sentence examples for mediating the efficient from inspiring English sources

The fact that attenuated VHL SUMOylation by inhibition of PIASy is likely to explain why VHL is still capable of mediating the efficient destruction of HIFα during hypoxia.

Here, we show that engineered histone H2B proteins are able to mediate the efficient delivery of either green fluorescent protein or DNA into HeLa cells through the process of "Histone-Mediated Transduction" (HMT), with further enhancement achieved by utilizing a dimer of histones H2B and H2A.

This unique localization of ABCG2 mediates the efficient pumping and hence concentration of multiple cytotoxic agents of distinct structure and mode of action (as well as non toxic compounds including riboflavin) from the cytoplasm into the lumen of EVs.

This balance is achieved through three, interconnected systems: First, promiscuity within the ligand specificity for transporters and drug metabolizing enzymes ensures that for any given chemical, whether it is endogenous or exogenous in origin, several complimentary systems can mediate the efficient removal of the stimulating chemical [5], [6], [7], [8], [9].

Although viral shRNA delivery mediated the efficient Azin1 knockdown in vitro, this did not reach significance in vivo.

Our results also suggest that another apical transporting sequence may lie outside of the 97 nt element, but that this sequence is unable to mediate the efficient anchorage or stability of the transcript at this site.

These results show that transporters ApST3 (as reported previously [ 13]) and ApST4 are functional hexose transporters that mediate the efficient transport of hexose sugars across the yeast plasma membrane.

Aquaporin 4 (AQP4), the main water channel in the brain, is expressed in pericapillary astrocyte foot processes, glial limiting membranes and ependyma [13, 14].This distribution suggests the involvement of AQP4 in the movement of water between blood and brain and between brain and cerebrospinal fluid, mediating the selective efficient movement of water across the cell membrane [15].

These studies have provided us with a clear rank order for the utility of this important class of enzymes as tools for vertebrate genome engineering with Bxb1 integrase mediating the most efficient and accurate site-specific recombination in this heterologous environment.

In an experiment comparing long, short, and intermediate hinges of a CAR against ROR1, the short-hinge CAR T cells mediated the most efficient response in terms of T cell killing and cytokine release, followed by the intermediate-hinge cells and the long-hinge cells [ 125].

The lack of cross-resistance to taxanes in MCF-7DOX cells also support the previous finding that ABCC1 may be more efficient in mediating the efflux of doxorubicin, but not taxane [ 19, 28].