Sentence examples for mediating the efficacy from inspiring English sources

To examine several psychological mechanisms mediating the efficacy of goal setting in endurance sports.

Neurotensin (NT) is a neuropeptide implicated in the pathophysiology of schizophrenia and in mediating the efficacy of antipsychotic drugs.

Although recent data highlight the requirement for innate sensors in cancer immunity, these canonical pathways including TLRs, inflammasome, and type I interferon/STING played no role in mediating the efficacy of CD40 and chemotherapy.

The importance of the FKBP12 complex in mediating the efficacy of BDE-4 toward RyR1 was further verified by measuring active uptake and release of Ca2+ from the same membrane vesicles used for [H]Ry binding analysis.

Thus, self-limiting the survival of SC vectors is also an important point, which is ideal for chemotherapy applications because the survival of delivered SCs needs to be no longer than sufficient duration for mediating the efficacy.

Thus, despite evidence suggesting a role for new born hippocampal neurones in mediating the efficacy of certain antidepressant compounds, a clear and coherent model explaining the mechanisms whereby adult born neurones contribute to emotional behaviours and/ or to the pathogenesis of depressive disorders remains to be formulated (Eisch and Petrik, 2012; Kheirbek et al., 2012).

This CIP2A-dependent p-Akt inhibitory mechanism that mediates the efficacy of bortezomib was confirmed in vivo in a nude mouse model.

Accumulating data support a relevant role of host immune responses in mediating the clinical efficacy of NC, particularly when using drugs with immunomodulating properties, such as taxanes [ 6].

Furthermore, given differences observed between the EGF- and HPX-induced transcriptional profiles, particularly for signalling ligands where the receptor also has strong increases in transcript abundance, such as HBEGF/EGFR and VEGFA/KDR, we hypothesised that pro-survival signalling through AKT may mediate the reduced efficacy of MEK-1/2 inhibitors under hypoxic conditions.

The specificity and efficacy of TFEB in mediating the clearance of toxic Tau species and rescuing neurodegeneration is remarkable.

Although self-efficacy appeared to be mediating the association because of the significant paths, the test was not significant (a*b = −0.055, BCa 95% CI: -0.120, 0.004).