Sentence examples for mediating the downstream from inspiring English sources

This finding implies that signaling nodes at PI3K-Akt is important for zebrafish hematopoiesis and angiogenesis, and might be involved in mediating the downstream signals of K-ras.

In our previous studies, no changes in the expression levels were found for the cell surface molecules or for the signalling molecules mediating the downstream signalling towards the release of proteases.

Further, we characterized role for dPGC-1 in mediating the downstream regulatory effects of INDY reduction, such as the observed changes in Indy mutant mitochondrial physiology, oxidative stress resistance and reduction of ROS levels.

The finding that NF- κB activation was only partially responsible for mediating the downstream effects of PKC was consistent with earlier findings that also the tyrosine kinase AP-1 pathway is involved in CCL2 induction elicited by high glucose concentrations in mesothelial cells [ 21].

Expression of a transient transfected HER3 in the SKBR3 cells prevented this decline, indicating that heterodimerization and crosstalk between HER2 and HER3 might be important in mediating the downstream pathway that leads to Akt activation in breast cancer cells after treatment with doxorubicin.

FRK has also been shown to have negative function on the stimulation of microvascular survival of the developing retina by mediating the downstream signaling of thrombospondin-1 and the thrombospondin receptor (CD36), which has been shown to antagonize VEGFA signaling of the Akt pathway (32).

Despite the importance of immune receptors to plant survival, few components that mediate the downstream signaling cascade have yet been characterized.

Because the XIK1 shares structural similarity with the LRR-RLK XA21, such as the extracellular LRR domain, a transmembrane domain that is required for the plasmembrane-localization of RLK proteins, and the intercellular active kinase domain, we suggest that XIK1 might work as a co-receptor of XA21 for PAMPs recognition and mediate the downstream signaling.

The PAK is another effector of Rac1 which works to mediate the downstream signaling of Rac1.

Also, the potent anti-tumor or anti-viral activity of NKT cells may be most beneficial under activation conditions that preferentially favor the development of either NKT1 or CD4− NKT cells, which can potently mediate the downstream activation of NK cells and CD8+ cytotoxic T lymphocytes, further amplifying anti-tumor or viral activity.

At the cellular level, three major signalling pathways mediate the downstream effects of EGFR activation.