However, the mechanisms mediating the down-regulation of the immune response and the granuloma pathology remain largely unknown.
The p38 pathway also participates in the apoptotic response, by mediating the down-regulation and degradation of the phosphorylated TP63 transcription factor, which binds p53 promoter DNA [16].
Alternatively, other mechanisms different from transcriptional repression could be mediating the down-regulation of NP-responsive genes.
Additionally, we also investigated the role of PKC in mediating the down-regulation of AQP4 expression induced by HS in primary astrocytes.
In addition to mediating the down-regulation of Bcl-2 and up-regulation of Bim, CHOP also induces expression of the pro-apoptotic proteins ERO1α and Puma [ 1– 3, 19, 21].
However, the steps that mediate the down-regulation of p38 by PKA still need to be identified.
AP-1 is a key cellular protein complex through which Nef mediates the down-regulation of MHC-I [10].
It was found that part of the specific domain can bind to NCS-1 and this interaction may mediate the down-regulation of N-type calcium channels [24], [26].
The elucidation of the mechanisms that could mediate the down-regulation of Ip awaits further studies.
Expression of rTSβ correlates with the production of small molecules that appear to mediate the down-regulation of thymidylate synthase protein by a novel intercellular signaling mechanism [ 2].
Inhibition of TRPV1 or Cx43 by capsazepine or 18α-GA and exposure to EGTA mediated the down-regulation of Cx43, CaMKII, PPARδ and HSL in 3T3-L1 preadipocytes.
