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In contrast, the UPR is not capable of mediating the correct folding and secretion of the majority of mutant matrilin-3 (V194D), which appears to accumulate in the rER of chondrocytes and eventually leading to dysregulated apoptosis [ Leighton et al., 2007].
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This dual mode of action mediates the correct assembly of the respiratory complex.
This indicates that binding of the enzyme to its substrate is not the unique determinant for an efficient recombination but that proficient synaptic complex formation, mediated by the correct folding and oligomerization of the protein on the substrates, could be the limiting step of the process.
Chaperones are defined as a family of protein that mediates the correct assembly of other polypeptides but that are not components of the functional assembled structures.
The biogenesis of this subcellular compartment is dependent on the concerted contribution of both the exocytic and endocytic systems, with an array of signals that mediate the correct protein sorting to these organelles [41], many of which remain still unknown.
It's about mediating the journey".
The university has been mediating the dispute.
It's been involved in mediating the Nagorno-Karabakh conflict.
GEMC theory posits that dynamic gestures mediate the generation of correct mathematical insight during proof production.
One of the direct transcriptional targets of β-catenin is Ephrin receptor B2 (EPHB2), whose protein product mediates the bi-directional migration and correct positioning of the cells along the crypt axis in the intestinal epithelium [ 3].
The mechanism by which Par-1 mediates sensing of the correct centrosome position is unknown.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com