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Several mechanisms are likely to be involved in mediating the consequences of childhood trauma at the molecular level, with interactions between childhood trauma and genetic variants, epigenetics mechanisms and shortened telomere length being only a few.
Certainly, modulation of homeostatic processes that favour neuroprotection over damaging chronic inflammation appears to be a key factor in mediating the consequences of glial activity.
Given the strong interrelationship between neuroactive steroid pathways and 5-HT2 receptors (60 62), it is possible that these systems may play a critical role in postnatal life in mediating the consequences of early stress.
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The consequences of exogenous HA or inhibition of endogenous HA show that CD44 mediates the consequences of HA on keratinocyte function [ 4, 6, 60, 99].
According to a study based on 842 faculty members' perceptions of responses to plagiarism, perceptions of severity of the offense strongly mediated the consequence that they recommend (Robinson-Zañartu et al. 2005).
Indeed, it was recently suggested that FGF21 may play a role in mediating the physiological consequences of TZD treatment [ 7].
Our findings provide mechanistic insights into the interaction between inflammation and neurocognitive performance, specifically implicating circulating cytokines and midbrain dopaminergic nuclei in mediating the psychomotor consequences of systemic infection.
Taken together, our findings provide mechanistic insights into the interaction between inflammation and neurocognitive performance, implicating circulating cytokines and midbrain dopaminergic nuclei in mediating the psychomotor consequences of systemic infection.
To confirm that these differentially expressed genes were indeed mediating the observed consequences of EZH2 knock down, BCL2, and FOXM1, which were down regulated upon EZH2 depletion, were individually targeted using siRNA.
The hypothesis that perception of consequences mediated the effect of arousal on sexual coercion was partially supported.
Perceived treatment consequences mediated the effect of objective clinical benefits on satisfaction with and preference for the study medication.
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