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Noradrenergic pathways are involved in mediating the central and peripheral effects of physiological arousal.
Wild type mice were injected unilaterally with a recombinant adenovirus-associated virus producing a localized increase in NPY expression (rAAV-NPY+) in the hypothalamus, targeting the arcuate nucleus (Arc) (Figure 4a), the brain region critical in mediating the central effects of Y receptor signaling on both energy balance and bone mass [6], [8].
These data identified novel regulators, endogenous receptors, in determining local clock activity, in addition to mediating the central control.
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Activation of the neurons in the trigeminal ganglion leads on the other hand to an activation of neurons in the trigeminocervical complex that project to the central nervous system (CNS) and mediate the central aspects of pain [1, 9].
α2-ARs are G-protein coupled receptors that mediate the central and peripheral actions of the primary sympathetic neurotransmitter, NE and the adrenal hormone epinephrine through the intracellular suppression of cAMP [11].
Considering the small size of these hydrophobic sequences, it is unlikely that it exerts a catalytic function, but interactions with conserved transmembrane proteins could mediate the central TMD function.
Note that the annotation matched two different maize transcripts to the same Arabidopsis gene (PFK3), which explains the different phase values shown in Table 2. PFK enzymes mediate the central regulatory step of glycolysis.
Thus, the identification of UBE2T as the 18th FA gene is consistent with current models of the FA pathway and confirms again the intimate connection between the 'early' proteins in the FA pathway, including FANCA/B/C/E/F/G/L/M and UBE2T (T), which together mediate the central step activation step, monoubiquitination of FANCD2 and FANCI.
Changes in the expression of these neuropeptides in the ARH are regarded as a key mechanism mediating the insulin effect in the central nervous system.
The transcription factor Hac1p is the central regulator mediating the UPR [ 30, 31].
In this paper a model is proposed which is focussed on activity interference as a central component mediating the relationship between noise exposure and annoyance.
More suggestions(15)
mediating the direct
mediating the toxic
mediating the proper
mediating the rapid
mediating the local
mediating the deleterious
mediating the therapeutic
mediating the stimulatory
mediating the proliferative
mediating the selective
mediating the detrimental
mediating the angiogenic
mediating the oncogenic
mediating the behavioral
mediating the specific
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Justyna Jupowicz-Kozak
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