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The aim of this study was to investigate the roles of nucleotide-binding oligomerization domain-containing protein 1/2 (NOD1/2) and Toll-like receptor 4 (TLR4) in mediating the adhesion of monocytes to periodontal fibroblasts through leucocyte function-associated antigen-1 (LFA-1) and very late antigen-4 (VLA-4).
The integrins are a family of heterodimeric receptors that play a universal role in mediating the adhesion of cells to the extracellular matrix.
Outer membrane proteins (OMPs) play important roles in the interaction with the host by mediating the adhesion to the mucosa and, therefore, the colonisation of the stomach and modulating the host immune response.
Evani et al found that monocytes have a role in tumour metastasis in breast cancer by mediating the adhesion of tumour cells to the endothelium (Evani et al, 2013).
These observations conflict with Ohmura et al. (1996) [ 118] who proposed that the formation of flagella was a major factor mediating the adhesion of A. ferrooxidans ATCC 23270 to solid sulfur surfaces.
Given that these two proteins are particularly important in mediating the adhesion and activation of T cells on antigen-presenting cells, we examined these proteins for their ability to capture a transgenic murine T cell line [ 20] specific for the pigeon cytochrome c (PCC) antigen.
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Together, the CAMs mediate the adhesion response to external stimuli, and inside-out signaling transduction.
To mediate the adhesion processes, polymeric coatings have been used to functionalize surfaces to introduce diverse physicochemical properties.
In 2000, Cirulli et al. demonstrated that αvβ3 and αvβ5 integrins could mediate the adhesion and migration of putative endocrine precursors [12].
Finally, TNFSF4 expressed on endothelial cells was reported to mediate the adhesion of TNFRSF4-expressing T-cells to vascular endothelial cells and the subsequent migration to distant inflammatory sites [35], suggesting an involvement of TNFSF4 in lymphocyte recruitment as well.
It is not clear how selectins mediated the adhesion of HT29 cells to the lung endothelium.
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