Sentence examples for mediating the activation from inspiring English sources
The protective role of ATM is probably through mediating the activation of Akt, which is activated in response to growth factors in neuronal cells.
Overall our studies have identified PINK1 as an upstream kinase of ubiquitin Ser and revealed a critical requirement of ubiquitinPhospho−Ser65 in mediating the activation of Parkin E3 ligase activity.
In fact, ATM is a nuclear protein kinase that functions as a signal transducer in response to DNA damage, but has also a cytoplasmic localization mediating the activation of Akt through a growth factor-mediated signaling pathway [ 18].
It also discusses the cellular biology of SR-BI, its activities in lipid transfer between HDL and cells, its role in mediating the activation of cellular signaling pathways by HDL in various cell types, and their possible contribution to atheroprotection.
To assess the importance of the interface residues in mediating the activation of full length MST3 by MO25, we compared basal and MO25-stimulated activity of full length MST3 and the crystallised MST3 (19–289) fragment.
VEGF-A binds to VEGFR-1 and -2, mediating the activation of all pathways required in angiogenesis.
In vivo, FasL expression is mainly detected in hematopoietic cells where it has a key role in the induction of cell death by mediating the activation-induced cell death of T lymphocytes, therefore contributing to the cytotoxic effector function of T and NK cells.
TRAF6 mediates the activation of mitogen-activated protein (MAP) kinases such as p38, Erk and JNK, and NF-κB transcription factors.
PRKCA can promote cell growth by phosphorylating and activating RAF1, which mediates the activation of the MAPK signaling pathway.
THBD is part of the anticoagulant pathway that mediates the activation of zymogen Protein C to activated Protein C (APC).
p38 activity has been previously shown to mediate the activation of MK2/3 upon stimulation by stress signals or by several inflammatory cytokines [9], [31].
