Sentence examples for mediating the aberrant from inspiring English sources

The results presented herein also reinforce the central role of mitochondrial dysfunction in mediating the aberrant effects of MeHg in vivo, as well as the role of TrxR as a molecular target for MeHg in the rat.

Although transcriptional deregulation has a central role in a large array of cancers including acute leukaemia, it is evident that epigenetic machineries including DNA methylation and post-translational histone modifications constitute integral functions of the oncogenic transcriptional complexes in mediating the aberrant transcriptional programmes (Cheung and So, 2011).

We suggest that down-regulation of developmental transcription factors may mediate the aberrant differentiation in ccRCC.

64 The pathogenetic mechanisms involved include AGE accumulation in ocular tissues where they mediate the aberrant cross-linking of extracellular matrix proteins and the disruption of endothelial junctional complexes that affects cell permeability and mediates angiogenesis.

Furthermore, plasma NOx levels were similar in both groups, which suggests that excess NO production did not mediate the aberrant vascular contractility observed in this model of inflammatory arthritis.

An over-reactive limbic system, which includes our amygdala (our fear center), is hypothesized to mediate the aberrant conditioning process in which a hormonal response is fixed to a memory [ 43].

They found 22 transcription factors with binding sites in at least eight DHSs that are located in established GWAS loci, and generated an immune regulatory network involving STAT1, STAT3, NF-κB and PPAR-γ that is highly likely to mediate the aberrant expression associated with disease [ 65].

At a functional level, we show that hallmarks of cancer, such as inhibition of cell differentiation and evasion of cell death in high-grade breast cancer cells, are mediated through the aberrant expression of UCP2, a mitochondrial protein.

Our findings suggest that the incomplete epigenetic remodeling observed for the 2,087 DMCpGs identified in iPSC‐derived DAn from PD patients might be mediated by the aberrant downregulation of a network of key TFs whose deficiency could prevent their target sites to become demethylated during the differentiation from iPSCs to DAn.

Aberrant activation of these pathways alters the expression of various critical target genes mediating the processes of apoptosis, proliferation and angiogenesis.

In contrast, the other two are non-native oligomers in which the native dimer interface and the electrostatic loop mediate the formation of aberrant intermolecular interactions.