Sentence examples for mediating synaptic transmission from inspiring English sources
Here, we describe use of the model SCG neuronal synapse to elucidate function of presynaptic proteins in mediating synaptic transmission.
Human acetylcholinesterase (hAChE), an enzyme mediating synaptic transmission, is a typical case of a human protein that necessitates mammalian systems to obtain functional expression.
The major nicotinic receptor mediating synaptic transmission in autonomic ganglia is a heteropentamer of α3 α5) β4 subunits [ 15, 33].
DOI: http://dx.doi.org/10.7554/eLife.01206.002 Physiological studies have pointed increasingly to a central role played by asynchronous release in mediating synaptic transmission (Goda and Stevens, 1994; Lu and Trussell, 2000; Hefft and Jonas, 2005; Iremonger and Bains, 2007; Best and Regehr, 2009).
The P2RX1 receptor functions in mediating synaptic transmission from neurons to smooth muscle, and driving vasoconstriction.
Since the rescue of aldicarb hypersensitivity, but not molting or development, by full length APL-1 is dose dependent, this result further strengthens the notion that APL-1 directly mediates synaptic transmission independent of molting.
Frequency histograms revealing enhanced mEPSC amplitude after corticosterone treatment are shown in Figure 2C & D. Importantly, this indicates that corticosterone induced increments in surface GluR2 labelling are accompanied by enhanced AMPAR mediated synaptic transmission.
Eventually, Park et al. demonstrated that NPD1 is also a highly potent endogenous inhibitor of TPRV1, a negative regulator for spinal cord synaptic transmission, and consequently a suppressor of inflammatory pain [ 28]; NPD1 blocked TRPV1- and TNF- α-mediated synaptic transmission and long-term potentiation (LTP) in the spinal cord.
Ionotropic glutamate receptors (iGluRs) are tetrameric cation channels that mediate synaptic transmission and plasticity.
The dibutyryl derivative of guanosine 3'5'-monophosphate caused a depolarization of the postganglionic neurons, which is consistent with the possibility that guanosine 3'5'-monophosphate mediates synaptic transmission at muscarinic cholinergic synapses.
Another prospective pathway APL-1 may use to mediate synaptic transmission is the well studied EGL-30 G-protein coupled receptor pathway, which can modulate cholinergic signaling.
