Sentence examples for mediating synaptic plasticity from inspiring English sources

Here we show that cadherin adhesion molecules play a critical role in mediating synaptic plasticity and behavioral changes driven by cocaine.

Leu-enkephalin, an endogenous opioid peptide found in the hippocampal mossy fiber pathway, plays a critical role in mediating synaptic plasticity at the mossy fiber-CA3 pyramidal cell synapse.

However, the function of RECK in the adult brain in mediating synaptic plasticity in the mature hippocampus is unknown.

Among its targets, the Ca2+/CaM-dependent protein kinases I and IV (CaMKs) are capable of transducing intraneuronal signals, and these kinases are implicated in neuronal gene regulation that mediates synaptic plasticity in mammals.

Neuropeptide mediated synaptic plasticity is known to involve regulation of gene expression and chromatin structure [38].

A Neurexin/Neuroligin/Shank signaling pathway (Bourgeron, 2009) could not only be important to stabilize synaptic contacts, but also to mediate synaptic plasticity and maturation.

In the present study, we have identified IRS2 as a novel component of the signaling apparatus which mediates synaptic plasticity in the hippocampus.

Therefore, through its modulatory effect on ATF4, DISC1 might be involved in the regulation of the transcriptional events that mediate synaptic plasticity.

Interestingly, LTP can be modulated by other neurotransmitters such as dopamine and acetylcholine [ 37, 56] and the muscarinic M1 subtype of cholinergic receptors are known to mediate synaptic plasticity by inhibiting small-conductance Ca2+-activated potassium (SK) channels at hippocampal synapses [ 8, 13, 25].

In January 2016, he will begin his own laboratory at Johns Hopkins University, where he will study the membrane and protein dynamics that mediate synaptic plasticity.

Evidence from several elegant studies have suggested that opposing cellular actions of mBDNF and proBDNF mediate synaptic plasticity [55].