Sentence examples for mediating sensitivity to from inspiring English sources

These 680 mutations may also play a role in mediating sensitivity to T20, which binds to a fusion intermediate in gp41.

Early-life behavioral events, especially in infancy, appear to exert 'organizational' effects on the oxytocinergic system, mediating sensitivity to its effects (Feldman et al. 2013), although such processes have yet to be clearly elucidated in humans or other mammals.

In addition to our data showing an enhanced response of Apc-mutant breast cancer cells to SP600125, previous studies have indicated a role of APC in mediating sensitivity to the JNK inhibitor VIII [ 22].

As well as mediating sensitivity to lenalidomide in del 5q) cells, experimental evidence suggests that PP2A and CDC25C are integral to acquired resistance to lenalidomide therapy.

The biological function of the nickel toxicity modulating networks and resistance networks also highlight the pathways described above as well as identify components of the alkaline phosphatase pathway and THO nuclear complex as mediating sensitivity to nickel.

To determine the mechanism for the ability of Metnase to mediate sensitivity to Topo IIa inhibitors, we investigated whether Metnase levels affected the cellular apoptotic response to adriamycin.

Interestingly, glucosylceramides appear to mediate sensitivity to heat stable antifungal factor (HSAF), as, in addition to ΔBAR1 mutants, a glucosylceramide synthase deficient mutant of Yarrowia lipolytica is also resistant to HSAF.

Li et al (1997) reported that overexpression of p21WAF1/CIP1 in cells lacking functional retinoblastoma protein might mediate sensitivity to anticancer drugs by inhibiting E2F2 phosphorylation, which contributed to increased S-G2 cell cycle delay and increased cell susceptibility to apoptosis.

A determination of the factors that mediate sensitivity to As2O3 will allow the use of this agent in such a way as to optimize therapeutic outcomes and minimize toxicity in the treatment of various malignancies.

Among genes with known antioxidant function, the PF3D7_1438900 (thioredoxin peroxidase1), PF3D7_1457200 (thioredoxin 1), and PF3D7_1121600 (EXP1, an exported glutathione transferase which mediates sensitivity to artesunate [ 45]) genes are down-regulated in response to DHA in P. falciparum trophozoites (Additional file 4) and the orthologues in P. berghei (Additional file 5).

The short-wavelength-sensitive (SWS1) pigments mediate sensitivity to light in the violet to UV range.