For example, as mentioned above in NSCLC and prostate CSCs, SOX2 relies heavily on EGFR signaling for mediating self-renewal in CSCs.
Therefore, alternative signaling pathways mediating self-sufficiency in growth will need to be identified and targeted.
This suggested that the HMG domain alone is capable of mediating self-association, though the HMG domain may not be absolutely required for this association.
ALDH is a detoxifying enzyme responsible for the oxidation of intracellular aldehydes, thereby mediating self-protection and resistance to some alkylating agents used in cancer therapy [13].
Structural characterization by CD, DLS, and NMR revealed that, similar to Cby, Par-4 is partially disordered with a C-terminal coiled-coil domain mediating self-association.
Thus, the TERT low-complexity proline/ arginine/glycine-rich linker (termed the PAL) is a candidate region for mediating self-association of overexpressed TERT.
This enzyme is responsible for the oxidation of intracellular aldehydes, thereby mediating self-protection and resistance to some alkylating agents (e.g. cisplatin) used in cancer treatments [ 41].
Dancers are notably resistant to vertigo, and this vertigo resistance could be related to a relatively poorly developed WM network mediating self-motion perception.
Knapp reported that this A/G allele was associated with the outcome of HCV infection, OAS1 playing a greater role in mediating self-limiting versus persistent HCV infection, rather than when viral persistence is established [ 16].
Although it remained possible that the N-terminal regions within mouse and human FAN1 might be mediating self-association, sedimentation velocity analysis showed unambiguously that, like pFAN1, full-length mouse FAN1 is monomeric.
