Sentence examples for mediating responsiveness to from inspiring English sources

We found that silencing PPARγ expression in THP-1 cells impaired the induction of LXRα and ABCA1 gene expression normally observed with ghrelin (Fig. 1D), in line with an essential role of PPARγ in mediating responsiveness to ghrelin in macrophages.

For instance, regions within exons 11, 12a, and 12b affect transcriptional activator activity of human Meis1 proteins by mediating responsiveness to PKA and TSA (Huang et al. 2005; Shim et al. 2007), and inclusion of exon 12a lowers transcriptional activation in frogs and mammals (Yang et al. 2000; Maeda et al. 2001; Huang et al. 2005); (fig. 3).

Further studies are needed to understand the mechanisms by which T may mediate responsiveness to social threat in male primates.

Baseline and follow-up measurements of phenotypic variables (demographic, physiologic, and genetic) will facilitate the study of patient factors that may mediate responsiveness to different therapies.

These epigenetic features have allowed the demarcation of boundaries that redefine the minimal Runx2-P1 promotor to include a 336-bp sequence that mediates responsiveness to osteoblast differentiation.

Studies with IL-4 and IL-13 reporter mice have revealed the compartmentalisation of adaptive and innate cell populations mediating immune responsiveness to N. brasiliensis.

Although the opposite patterns of looking across the two experiments suggested the anxiety hypothesis, these data do not provide independent evidence that anxiety mediated responsiveness.

Other experiments using mice with a targeted mutation of the type I IFN receptor show that this pathway is required for type I interferon-mediated responsiveness.

Further, the N50 region of AR regulates the characteristics of inclusions formed and mediates its responsiveness to the anti-aggregation effects of Y-27632 and profilin.

Hence, as expected, subsequent rounds of ChIP resulted in an enrichment of SynCREs within the pool of immunopecipitated SynEs mediating expression and/or responsiveness to Pep25.

Consequently, we set out to determine the in vitro and in vivo response of BLCA tumour models to AKT inhibition and the molecular determinants and mechanisms involved in mediating and predicting responsiveness to AKT target therapy.