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Understanding the molecules and the pathways involved in mediating resistance is thus needed for a better clinical management of the disease.
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Finally, the P. falciparum chloroquine resistance transporter gene (pfcrt) was identified, and mutations mediating resistance were characterized and confirmed clinically [ 56, 57].
Unlike plasmid-mediated resistance, which may disappear in the absence of selective pressure, chromosomally mediated resistance is often maintained.
Lee et al. (2008) proposed a new model for plant disease resistance where R-gene mediated resistance is integrated into the basal immunity system of the plant and functions primarily to restore the innate immunity response that is actively suppressed by virulent pathogens[ 38].
The contribution of plasmid mediated resistance was similar in Nanjing in the period 2011 12 compared to 2006 [ 39], but during this interval declines in the proportion of PPNG have been observed in Korea [ 57], Canada [ 58], Latin America and the Caribbean countries [ 59].
A genotype of the virus that overcomes ref (2 ) P-mediated resistance is common in European populations (Fleuriet & Sperlich 1992; Fleuriet & Periquet 1993).
However, the mechanism by which homoserine accumulation in plant tissue mediates resistance is still not fully understood, and may be key to fully exploiting dmr1 based resistance which has the potential for use in multiple crop species.
Additional therapeutic strategies targeting molecular mechanisms-mediating resistance are required, either to delay or to prevent the emergence of the castration resistant phenotype [ 16].
However, resistance to chemotherapeutics is common, and the mechanisms mediating resistance have been difficult to determine.
In crizotinib-resistant tumors, several distinct bypass tracks mediating resistance have been reported.
Molecular and cellular mechanisms mediating resistance have been extensively studied.
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