Sentence examples for mediating regression of from inspiring English sources
The role of naturally occurring cytotoxic T cells (CTLs) in mediating regression of HPV-related disease has not been proven.
These cells could be converted into effector cells by in vitro expansion with anti-CD3mAB and IL-2 and were capable of mediating regression of established metastases following adoptive transfer (Yoshizawa et al, 1991).
Parkhurst, M. R. et al. T cells targeting carcinoembryonic antigen can mediate regression of metastatic colorectal cancer but induce severe transient colitis.
FOXO1 also mediates regression of cardiac hypertrophy by affecting autophagy [ 79].
IL10 is over expressed in breast tumours [ 16] and exogenous administration can mediate regression of tumour growth and breast cancer metastases in mice models [ 17].
Previous work has shown that CD8+ T cells are responsible for rejection of E.G7-OVA tumours and that administration of an anti-CD4 monoclonal antibody, that mediates regression of established E.G7-OVA tumours, leads to increased infiltration of CD8+ cells (Vasovic et al, 1997; Dyall et al, 1999).
Zhao, Y. et al. Multiple injections of electroporated autologous T cells expressing a chimeric antigen receptor mediate regression of human disseminated tumor.
Several studies have described a unique population of macrophages with properties of both inflammatory (M1) and tissue remodeling/fibrotic (M2) macrophages, termed scar-associated macrophages, arising from recruited Ly6Chi monocytes expressing high levels of MMP13 that mediate regression of liver fibrosis in animal models [86,131-136].
Studies in animals have shown that TRAIL mediates regression of cancer xenografts without affecting normal tissues, and human phase I studies have demonstrated that TRAIL agonists are safe [ 3, 6].
Mmp13 has been shown to be expressed by macrophages in murine livers where it is involved in mediating the regression of hepatic fibrosis [45] and MMP-13 activity against fibrinogen has been shown in vitro [46].
AMH mediates the regression of Müllerian ducts in the developing male fetus.
