This transporter mediates reabsorption of uric acid in proximal renal tubules to regulate blood uric acid level.
One member of the OAT family, urate transporter 1 (URAT1), is expressed in the brush border of the proximal renal tubule (brush border membrane) and mediates reabsorption of uric acid to regulate blood uric acid concentration.
In the nephron, SMIT1 mediates myo-inositol uptake as a 'compatible osmolyte' when inner medullary tubules are exposed to increases in extracellular osmolality, whilst SMIT2 mediates the reabsorption of myo-inositol from the filtrate.
However, an important factor limiting benefits of this therapy is the occurrence of radiation-induced nephropathy, which arises due to renal clearance and megalin-receptor mediated tubular reabsorption of the chelated somatostatin analogues [9, 10].
SMVT located in kidney proximal tubule epithelial cells mediates the reabsorption of biotin and pantothenic acid.
Second, the slow decrement in urinary [Cl−], resulting in an increased urinary [Na+]–[Cl−] difference, may be due to both a secondary increased activity of aldosterone, promoting a Cl−-independent cortical Na+ reabsorption, and a reduced activity of the luminal Cl−/HCO3 − exchanger pendrin, mediating Cl− reabsorption and HCO3 − secretion in type B cortical intercalated cells [37, 38].
In the proximal tubule, NHE3 is shown to be important as a part of driving force for Ca2+ reabsorption, mediating apical Na+ entry and consequently water reabsorption to produce osmotic gradient [ 18].
The increased sulfatemia in pregnant mice is due to increased expression of the renal Slc13a1 sulfate transporter, which mediates sulfate reabsorption in the maternal kidneys [ 25].
This mechanism results in the transfer of electron hole excitation between distant QDs mediated by the emission and reabsorption of the transverse electromagnetic field [12].
Additionally, the apically located NHE-1 could also mediate Na+ reabsorption in exchange with H+.
