Sentence examples for mediating protective immunity from inspiring English sources

To test the relative efficacy of CD4 and CD8T cells in mediating protective immunity to Mycobacterium tuberculosis (Mtb), we compared three immunization regimes designed to induce preferentially each subset.

Typically, helminths induce strongly polarised Th2 responses, which are often effective in mediating protective immunity against those parasites living at mucosal surfaces, but less so in protecting against tissue-dwelling parasites.

Although Th2-associated responses and high levels of IgE correlate with protection in gastrointestinal helminth infections [ 33], our data suggest that IgE may have a limited role in mediating protective immunity against T. crassiceps.

Currently there is much interest in its use for nucleic acid mediated immunizations; studies in the 1990s revealed that DNA vaccination could mediate protective immunity, as plasmid DNA incorporated into cells results in an antigen-specific antibody responses (see [ 8- 10] for reviews).

Ad-MSP-142 induces a strong antibody response after two weeks to the 19 kD fragment of MSP-1 (MSP-119), which is thought to mediate protective immunity [36], [37].

Studies have demonstrated that epitope-specific T cell responses elicited by immunization with DNA or peptide, and adoptive transfer of epitope-specific T cell clones, could mediate protective immunity, in some cases with single CTL epitopes, against various pathogens in murine experimental models [32] [42].

Sustaining this balance allows for adequate CD8+ lymphocyte-mediated protective immunity while avoiding the overaccumulation of activated T cells that can predispose to autoimmunity.

Besides CD4 T helper responses, it is know that CD8+ T cells may also mediate protective immunity against A. fumigatus infection, especially through recognition of HLA-A*0201 HLA-A*0201 fungal peptides [ 167].

Although it has been suggested that TCM has a better capacity to replenish memory T cell pool and to mediate protective immunity than TEM because of their greater capacity to proliferate and persist in vivo, the findings of Huster et al. show that TEM is crucial for providing efficient protective immunity against Listeria monocytogenes infection [ 19].

McCoy, K. D. et al. Polyclonal and specific antibodies mediate protective immunity against enteric helminth infection.

These cytokines form a complex network of molecular and cellular interactions that mediate protective immunity to worm infection, but also induce inappropriate inflammatory responses to allergic challenge.