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DROSHA (RNASEN) is RNAse III enzyme mediating processing of pri-miRNAs into pre-miRNAs with DGCR8.
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CBC recruits several factors to 7mG-modified transcripts which mediate processing events [ 34, 48, 49].
We developed an assay to monitor the in vivo processing of C. elegans ILPs and to identify the PC that mediates processing.
These potential SDR-mediated processing events were experimentally detected by the authors using the known SDR-containing sequences as probes for RT-PCR and subsequent DNA sequencing.
Cleaved caspase-1, an activated form that mediates processing of IL-1 β, IL-18, and apoptosis, was also detected in the supernatants of ATG16L1-deficient macrophages following LPS stimulation.
Pre-let-7 is mono-uridylated at the 3′ end by LIN28A and TUTases prior to Dicer-mediated processing.
These lines of evidence suggest that LIN28A might participate in multiple steps of let-7 biogenesis, including both Dicer- and Drosha-mediated processing.
A theoretical account is proposed emphasizing the influence of adaptive selection of strategies that mediate processing capacity constraints in reasoning development.
Further study is now in progress to discover other components, which might include RNA recognition/binding proteins in the RF2 fertility restoration-complex that mediate processing of a CMS-associated mitochondrial RNA.
Although uncertain whether or not the changes that they see are as a result of increased transcription, the effect of MicA-mediated processing is currently being addressed.
Our findings represent an extension of previous work from our group suggesting that proconvertases mediate processing of inhibin subunits in the pituitary [4].
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